The Mirena Intrauterine Therapy System (IUD) is a T-shaped levonorgestrel-releasing construct placed in a guidewire tube.
Pharmacodynamics
Mirena is an IUD that releases levonorgestrel and has mainly a local gestagenic effect. The gestagen (levonorgestrel) is released directly into the uterine cavity, which allows it to be used at an extremely low daily dose. High concentrations of levonorgestrel in the endometrium contribute to a decrease in the sensitivity of its estrogen and progesterone receptors, making the endometrium immune to estradiol and exerting a strong antiproliferative effect. When using the IUD Mirena®, morphological changes in the endometrium and a weak local reaction to the presence of a foreign body in the uterus are observed. An increase in the viscosity of the secretion of the cervix prevents the penetration of sperm into the uterine cavity, due to a decrease in sperm motility and changes in the endometrium, the likelihood of fertilization of the egg decreases. Some women also experience suppression of ovulation.
Previous use of the IUD Mirena does not affect the childbearing function. Approximately 80% of women who want to have a baby become pregnant within 12 months after the removal of the IUD.
In the first months of using the Mirena IUD, due to the inhibition of the process of endometrial proliferation, there may be an initial increase in spotting bloody discharge from the vagina. Following this, a pronounced suppression of endometrial proliferation leads to a decrease in the duration and volume of menstrual bleeding in women using the Mirena IUD. Scanty bleeding often transforms into oligo- or amenorrhea. At the same time, ovarian function and the concentration of estradiol in the blood plasma remain normal.
The Mirena IUD can be used to treat idiopathic menorrhagia, i.e. menorrhagia in the absence of hyperplastic processes in the endometrium (endometrial cancer, metastatic lesions of the uterus, submucosal or large interstitial myomatous node, leading to deformation of the uterine cavity, adenomyosis), endometritis, extragenital diseases and conditions accompanied by severe hypocoagulation (for example, von Willebrand disease, severe thrombocytopenia) symptoms of which is menorrhagia. After 3 months of using the Mirena® IUD, menstrual blood loss in women with menorrhagia is reduced by 62–94% and by 71–95% after 6 months of use. When using the IUD Mirena® for 2 years, the effectiveness of the drug (reducing menstrual blood loss) is comparable to surgical methods of treatment (ablation or resection of the endometrium). A less favorable response to treatment is possible with menorrhagia due to submucosal uterine myoma. Reducing menstrual blood loss reduces the risk of iron deficiency anemia. IUD Mirena reduces the severity of symptoms of dysmenorrhea.
The effectiveness of the Mirena IUD in preventing endometrial hyperplasia during chronic estrogen therapy was equally high with both oral and transdermal estrogen.
Payment and delivery:
Delivery MIRENA from Europe
Delivery MIRENA from the Czech Republic
Delivery MIRENA from Germany
Delivery MIRENA from Russia
Delivery MIRENA from France
Delivery MIRENA from Italy
Buy MIRENA in Europe
Buy MIRENA in the Czech Republic
Buy MIRENA in Germany
Buy MIRENA in Russia
Buy MIRENA in France
Buy MIRENA in Italy
Delivery of MIRENA in Moscow
Delivery of MIRENA in Kiev
Delivery of MIRENA in Minsk
Delivery of MIRENA in London
Delivery of MIRENA in St. Petersburg
Delivery of MIRENA in Kharkov
Delivery of MIRENA in Paris
Delivery of MIRENA in Madrid
Delivery of MIRENA in Munich
Delivery of MIRENA in Brussels
Delivery of MIRENA in Amsterdam
Delivery of MIRENA in Copenhagen
Order Form:
- The name of the medicine
- Dosage
- Brand
- Quantity
Send to e-mail doradorapharm@gmail.com
In search engines are looking for
Купить МИРЕНА, 1, Цена МИРЕНА, 1
Купити МИРЕНА, 1Ціна МИРЕНА, 1
Kupit МИРЕНА, 1Ceni МИРЕНА, 1
Buy MIRENA, 1, Price MIRENA, 1
Acheter MIRENA, 1, Prix MIRENA, 1
Para comprar MIRENA, 1, Precio MIRENA, 1
Zu kaufen MIRENA, 1, Preis MIRENA, 1
Kupić MIRENA, 1, Cena MIRENA, 1
Koupit MIRENA, 1, Cena MIRENA, 1
للشراء MIRENA, 1, السعر MIRENA, 1
Satın almak MIRENA, 1, fiyat MIRENA, 1
Comprare MIRENA, 1, prezzo MIRENA, 1
Sotib olish uchun MIRENA, 1, Narxlari MIRENA, 1
Για να αγοράσετε MIRENA, 1, Τιμή MIRENA, 1
შეძენა MIRENA, 1, ფასი MIRENA, 1
Satın almaq üçün MIRENA, 1, Qiymət MIRENA, 1
Para comprar MIRENA, 1, Precio MIRENA, 1
Comprar MIRENA, 1, Preço MIRENA, 1
Popular medicine from Czech Republic, to buy medicine from France, delivery of medicine from Germany, how to buy medicine from Czech Republic to America, how to buy medicine from France to England, Online Pharmacy from Germany, Internet Pharmacy from Czech Republic, International Pharmacy in Europe, Pharmacy from Europe, Medical cosmetics from France, Natural cosmetics from Europe or Canada, Vitamins from Europe or America, Nutritional supplements from Europe and Poland, Products from Czech Republic, to order medicine from Germany
Popular prescription drugs from the Czech Republic, to buy prescription drugs from France, delivery of prescription drugs from Germany, how to buy prescription drugs from the Czech Republic to America, how to buy prescription drugs from France to England, how to order prescription drugs from Europe, delivery of prescription drugs from Europe and across Euro